Identification of glycoprotein nonmetastatic melanoma protein B (GPNMB) receptor and effect of GPNMB in higher brain function

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460103
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pharmacology in pharmacy
• Research Institution: Gifu Pharmaceutical University
• Principal Investigator: Hara Hideaki 岐阜薬科大学, 薬学部, 教授 (20381717)
• Co-Investigator(Kenkyū-buntansha): TSURUMA Kazuhiro 岐阜薬科大学, 薬学部, 講師 (50524980)
• Co-Investigator(Renkei-kenkyūsha): 青木 正志 東北大学, 医学系研究科, 教授 (70302148)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: GPNMB / 記憶 / GluA1 / Na+, K+-ATPase / PI3K/Akt経路 / MEK/ERK経路

Outline of Final Research Achievements

The aim of this study was to lead to development of effective novel treatment for GPNMB related diseases by investigating whether GPNMB affects to memory and by identifying of novel GPNMB extracellular fragment receptors.
We found that GPNMB promoted hippocampus-dependent memory by increasing expression levels of total GluA1 proteins and phosphorylated GluA1 proteins. Moreover, we also found that GPNMB extracellular fragment bound to Na+, K+-ATPase (NKA) α1 and NKA α3 and activated PI3K/Akt pathway and MEK/ERK pathway via NKA α1 and α3. Therefore, it was suggested that NKA α1 and α3 work as a novel GPNMB extracellular fragment receptor.

Free Research Field

神経化学、眼科学、薬理学