New therapeutic approach of myofibrillar myopathy by mitochondrial protection

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460105
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pharmacology in pharmacy
• Research Institution: Iwate Medical University
• Principal Investigator: Sanbe Atsushi 岩手医科大学, 薬学部, 教授 (30425706)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 心筋症 / 熱ショックタンパク質 / ストレス / アポトーシス

Outline of Final Research Achievements

It is hypothesized that BCL-2 associated athanogene (BAG) 3 can play an important role in cytoprotective effect of BCL-2, antiapoptotic factor, by direct protein-protein interaction. We examined changes in BAG3 level in myocardium in myofibrilallar myopathy (MFM) mouse model. In MFM mouse heart, marked increase in BAG3 level was detected. In order to analyze the role of BAG3 in cardiomyocytes, knockdown approach using si-RNA targeting to BAG3 was performed. The knockdown of BAG3 enhanced apoptotic cell death in cardiomyocytes. These results suggest that BAG3 may play a protective role in cardiomyocytes.

Free Research Field

薬理学