Study on incretin-mediated glucagon secretion in the onset and development of diabetes mellitus

2016 Fiscal Year Final Research Report

• Project/Area Number: 25460113
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pharmacology in pharmacy
• Research Institution: Meiji University of Integrative Medicine
• Principal Investigator: KATSURA Masashi 明治国際医療大学, 医学教育研究センター, 教授 (80204452)
• Research Collaborator: SHIGETO Makoto ; KAKU Kohei
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: インスリン分泌 / 膵島細胞 / GLP-1 / Aキナーゼ / Cキナーゼ

Outline of Final Research Achievements

Strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like peptide 1 (GLP-1) therapeutically improve glucose-stimulated insulin secretion (GSIS); however, it is not clear whether GLP-1 directly drives insulin secretion in pancreatic islets. In the present study, we examined the mechanisms by which GLP-1 stimulates insulin secretion in mouse and human islets.
Based on results using high concentration of GLP-1, the mechanism of action of GLP-1 has been considered to be PKA-dependent. But it was revealed that at physiologically low concentration of GLP-1, PKC-dependent pathway promotes insulin secretion.

Free Research Field

薬理学