2015 Fiscal Year Final Research Report
Development of novel transcription modulators based on de novo design of scaffolds
| Project/Area Number |
25460146
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Fujii Shinya 東京大学, 分子細胞生物学研究所, 講師 (60389179)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 生物活性化合物 / 転写因子 / ステロイドホルモン / アンドロゲン受容体 / プロゲステロン受容体 / グルココルチコイド受容体 / ケイ素 |
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| Outline of Final Research Achievements |
In this research, development of novel biologically active compounds based on de novo design of scaffolds, with focusing on the pharmacophores of biologically active natural products, was investigated. Based on the structures of several natural products including curcumin, various modulators for nuclear receptors such as androgen receptor and progesterone receptor were developed. The developed compounds are versatile lead compounds for drug discovery, and the methodology developed here is also a promising approach for structural development.
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| Free Research Field |
創薬化学
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