2015 Fiscal Year Final Research Report
Analysis of activation of cellular immunity through intestinal immunity to develop versatile oral adjuvants for treatment of viral infection.
| Project/Area Number |
25460183
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Kyushu University of Health and Welfare |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE wataru 九州保健福祉大学, 大学院医療薬学研究科, 教授 (50399218)
YOSHIDA hiroki 九州保健福祉大学, 大学院医療薬学研究科, 講師 (90469411)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 細胞性免疫 / 腸管免疫 / 経口アジュバント / プロポリス / モリンガ葉 / 乳酸菌 |
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| Outline of Final Research Achievements |
Our aim in this project is to search oral antigens that are able to activate cellular immunity through intestinal immunity and clarify the mode of the activation. It is known that a major immune defense system in intradermally herpes simplex virus-infected mice is a delayed type hypersensitivity reaction through Th1 immunity. Using this model, we demonstrated that Lactobacillus plantarum strain 06CC2 and aqueous extract of Moringa oleifera Lam. leaves (AqMOL) as well as propolis AF-08 that we found previously were significantly effective in alleviating herpetic symptoms by the activation of Th1 immunity through intestinal immunity. Thus, the three daily supplements, 06CC2, AqMOL, and AF-08 were suggested to be useful as a versatile oral adjuvant for treatment of viral infection.
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| Free Research Field |
ウイルス学、免疫学、生化学
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