The influence of 5-alpha-reductase inhibitors for erectile function and cardiovascular function

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460218
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Nagoya City University
• Principal Investigator: Kimura Kazunori 名古屋市立大学, 医学(系)研究科(研究院), 教授 (00423848)
• Co-Investigator(Kenkyū-buntansha): MAEDA Yasuhiro 名古屋市立大学, 大学院薬学研究科, 講師 (60275146) ; HOTTA Yuji 名古屋市立大学, 大学院薬学研究科, 助教 (90637563)
• Co-Investigator(Renkei-kenkyūsha): SASAKI Shoichi 名古屋市立大学, 大学院医学研究科, 准教授 (50225869)
• Research Collaborator: KATAOKA Tomoya 名古屋市立大学, 大学院医学研究科, 助教 (20737928)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 5α還元酵素阻害剤 / 勃起障害 / 動脈硬化 / 血管内皮機能 / ジヒドロテストステロン / テストステロン / 酸化ストレス / 一酸化窒素

Outline of Final Research Achievements

5-alpha-reductase inhibitors are used for Androgenetic Alopecia or benign prostatic hyperplasia from 2005. One study reported that 6 months of 5-alpha-reductase inhibitors therapy caused ED at 3 months and at 6 months. Erectile function have close relationship to cardiovascular function. We investigated the erectile function and cardiovascular function in animal model.
5-alpha-reductase inhibitors decreased the erectile function in rats at 4 weeks and 8 weeks. However, the endothelial function of the rats’ aorta was not changed.

Free Research Field

臨床薬学