Study on the biomarkers predicting age-related diseases

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460233
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Kinki University (2015); Kobe Pharmaceutical University (2013-2014)
• Principal Investigator: MIZUNO Shigeto 近畿大学, 医学部附属病院, 教授 (80368349)
• Co-Investigator(Kenkyū-buntansha): WATANABE Yoshiyuki 京都府立医科大学, 医学研究科, 教授 (00191809) ; KURIYAMA Nagato 京都府立医科大学, 医学研究科, 准教授 (60405264) ; INUI Akio 鹿児島大学, 医学部, 教授 (80168418) ; ASAKAWA Akihiro 鹿児島大学, 医学部, 准教授 (10452947)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 骨粗鬆症 / ヘリコバクター・ピロリ / 慢性萎縮性胃炎

Outline of Final Research Achievements

We intended to ascertain whether serologically determined Helicobacter pylori infection and consequent atrophic gastritis is available as a biomarker for the age-related deterioration of bone. The subjects are male participants of the Japan Multi-institutional Collaborative Cohort Study in their 50s and 60s.
Helicobacter pylori infection significantly increased the risk of low trabecular bone density (odds ratio 1.83, 95 % CI 1.04-3.21, P = 0.03). Atrophic gastritis significantly increased the risk of low trabecular bone density (2.22, 1.17-4.22, 0.01). Compared with anti-Helicobacter pylori antibody (-) and atrophic gastritis (-) subjects, anti-Helicobacter pylori antibody (+) and atrophic gastritis (+) subjects were a significant high-risk group for low trabecular bone density (2.65, 1.27-5.55, 0.01).

Free Research Field

消化器内科学