2015 Fiscal Year Final Research Report
Analysis of cancer cell clock for chronotherapy
| Project/Area Number |
25460309
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 時計遺伝子 / 癌 / 低酸素 |
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| Outline of Final Research Achievements |
When we consider the strategy of chronotherapy, it is important to know architecture of biological clock oscillation of treatment resistant hypoxic area in cancer tissue. In this project, the effects of hypoxia to cancer clock were examined. Oxygen concentration and timing dependently hypoxic pulse phase shifted cancer clock. Magnitude of phase shift of cancer clock by hypoxic pulse was attenuated by suppression of pH reduction by addition of buffer. Hypoxic pulse increased clock genes, Per1 and Dec1, expressions which were not affected by suppression of pH reduction. From these findings, we can speculate the condition of clock oscillation in hypoxic area of cancer tissue.
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| Free Research Field |
時間生物学
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