2015 Fiscal Year Final Research Report
Neural mechanism regulating body weight and glucose metabolism via orexin receptors
| Project/Area Number |
25460318
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKASE Kenkichi 自治医科大学, 医学部, 教授 (80381474)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 体重制御 / 神経ペプチド / 糖代謝 |
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| Outline of Final Research Achievements |
We examined the body weight regulation via hypothalamic neuropeptides. We showed the differential roles of orexin receptors in energy metabolism. Orexin receptor signalings enhance mTORC1 singaling. Orexin-overexpression mice fed with a high-fat diet showed stronger mTORC1 signaling in their brains. Meta-analysis revealed that MCH-signaling-deficient mice suppress body weight gain due to increased energy expenditure.
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| Free Research Field |
神経科学
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