Molecular aberrations in intestinal B-cell lymphomas: comprehensive analyses for chromosomal translocations and microRNA expression.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460418
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Iwate Medical University (2014-2015); Kyushu University (2013)
• Principal Investigator: NAKAMURA SHOTARO 岩手医科大学, 医学部, 准教授 (10243932)
• Co-Investigator(Kenkyū-buntansha): MATSUMOTO Takayuki 岩手医科大学, 医学部, 教授 (10278955) ; ODA Yoshinao 九州大学, 医学研究科(研究院), 教授 (70291515) ; HASHIZUME Makoto 九州大学, 医学研究科(研究院), 教授 (90198664) ; HIRAHASHI Minako 九州大学, 医学研究科(研究院), 講師 (90529877) ; GOTOH Akinobu 兵庫医科大学, 医学部, 教授 (70283885)
• Co-Investigator(Renkei-kenkyūsha): TAKESHITA Morishige 福岡大学, 医学部, 教授 (90171636)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 消化管リンパ腫 / DLBCL / MALTリンパ腫 / FISH / 転座 / IGH / microRNA

Outline of Final Research Achievements

1) We investigated the significance of chromosomal translocations in small bowel diffuse large B-cell lymphomas (DLBCLs). Translocations involving IGH, BCL6, MYC and BCL2 were detected in 23 (70%), 12 (36%), 8 (24%) and 6 (18%) of 33 cases, respectively. Univariate analyses demonstrated young age, low international prognostic index, IGH-translocations, extra-copies of MALT1/BCL2, and BCL6 immunoexpression to be better overall survival (OS) and progression-free survival (PFS). Cox multivariate analysis revealed IGH-translocations to be an independent prognostic factor for better PFS, but not OS. In conclusion, IGH-translocations are frequent in small bowel DLBCLs, and this translocation may be predictive of favorable prognosis.
2) We comprehensively investigated dysregulation of microRNA expression in representative cases of gastrointestinal MALT lymphoma. Increases and decreases of miroRNAs were identified in 15 and 13 miroRNAs, respectively.

Free Research Field

消化器内科学