New stratification of malignant lymphoma from the point of view of the cancer-initiating cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460435
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Osaka University
• Principal Investigator: IKEDA JUNICHIRO 大阪大学, 医学(系)研究科(研究院), 准教授 (20379176)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 癌 / 悪性リンパ腫 / 腫瘍幹細胞 / 病理学 / アルデヒド脱水素酵素 / 活性酸素 / FoxO3a / ID1

Outline of Final Research Achievements

Cells with cancer initiating cell character in Hodgkin lymphoma have a high expression of the transcription factor FoxO3a which regulate enzymes to degrade reactive oxygen species. We examined the expression of FoxO3a in malignant lymphoma cases. FoxO3a expression was often observed in nodular sclerosis classical Hodgkin lymphoma, and FoxO3a expression was inversely correlated with the inhibitor of DNA binding (ID) protein 1 expression. The expression of FoxO3a and ID1 could be regulated by Epstein-Barr virus (EBV)-encoded latent membrane protein 1. These results suggested that the relationship between FoxO3a and ID1 through EBV infection might play an important role in tumorigenesis of Hodgkin lymphoma.

Free Research Field

医歯薬学