2015 Fiscal Year Final Research Report
Metabolic factors reflecting thrombogenicity of atherosclerotic plaque
| Project/Area Number |
25460440
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORIGUCHI SAYAKA 宮崎大学, 医学部, 助教 (90468041)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 動脈硬化性血栓 / プラークの血栓能 / 代謝 / 低酸素 |
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| Outline of Final Research Achievements |
Atherosclerotic plaque disruption does not always result in acute symptomatic events. Therefore, the thrombogenicity of the atherosclerotic plaques is a critical factor in the development of atherothrombosis. However, little is known about determinants of the plaque thrombogenicity. We found that metabolite levels of glycolysis increase in macrophage-rich atherosclerotic arteries, and that arterial glucose uptake reflects vascular thrombogenicity, which might be partly explained by metabolic adaptation and enhanced procoagulant activity in a hypoxic microenvironment. Expression of hexokinase II, a glycolytic enxyme upregulated by hypoxia, in the atherosclerotic plaques correlated with human coronary thrombus size. The novel findings will allow the detection of high-risk plaques and the development of atherosclerosis therapies.
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| Free Research Field |
血栓症
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