2015 Fiscal Year Final Research Report
Development of oncolytic adenovirus as a new therapeutic agent for treating disseminated cancers
| Project/Area Number |
25460484
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
Kubo Shuji 兵庫医科大学, 医学部, 准教授 (10441320)
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| Co-Investigator(Kenkyū-buntansha) |
YAMANO TOMOKI 兵庫医科大学, 医学部, 講師 (00599318)
OHYAMA HIDEKI 兵庫医科大学, 医学部, 非常勤講師 (90280685)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 遺伝子治療 / 腫瘍溶解ウイルス / 癌 |
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| Outline of Final Research Achievements |
Disseminated cancers are generally non-curative and novel therapeutic paradigms are urgently required. We developed dual-targeted oncolytic type 5 adenoviruses in which the viral replication was regulated by cancer-specific promoter and the receptor-binding site in the fiber was modified to target CD46 that was highly expressed in most cancer cells. We then examined the anti-tumor effects in various cancer models.
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| Free Research Field |
遺伝子治療
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