2015 Fiscal Year Final Research Report
Immune regulation though C-type lectin using microbial polysaccharides
| Project/Area Number |
25460494
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INABA Kayo 京都大学, 大学院生命科学研究科, 教授 (00115792)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | C. albicans / C型レクチン / 糖鎖 / IL-10 / 免疫制御 |
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| Outline of Final Research Achievements |
In 1970s, it was reported that there was immunosuppressive factor(s) in serum of Candidiasis patients. In this study, the immunosuppressive effects of N-glycan purified from C. albicans surface mannoprotein. After injection of the N-glycan with lipopolysaccharide, up-regulation of immunosuppressive cytokine IL-10 in serum, but not IFN-g and TNF-a was observed. In a lethal model of sepsis, the N-glycan ameliorated survival rate of mice. These results suggest that N-glycan from C. albicans surface mannoprotein suppresses immune response thought augmentation of immunosuppressive IL-10 production.
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| Free Research Field |
免疫学
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