Possibility of a new biomarker in the diagnosis of primary aldosteronism

2016 Fiscal Year Final Research Report

• Project/Area Number: 25460668
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Hokkaido University
• Principal Investigator: JIN SHIGEKI 北海道大学, 保健科学研究院, 助教 (60531845)
• Co-Investigator(Renkei-kenkyūsha): CHIBA Hitoshi 北海道大学, 大学院保健科学研究院, 教授 (70197622) ; HUI Shu-Ping 北海道大学, 大学院保健科学研究院, 教授 (90337030)
• Research Collaborator: WADA Norio 市立札幌病院, 内分泌内科, 医師
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 臨床検査医学

Outline of Final Research Achievements

Primary aldosteronism is considered as approximately 10% of the causes of hypertension, so the diagnosis of its subtype is crucially important issue because cures are required on different kind of subtype. In this study, we found the substance which was detected more amount in the aldosterone-producing adenoma (APA) patient urine than that in the other subtypes of primary aldosteronism. We investigated the possibility of employing this substance as a new biomarker. The substance was detected as 1.5-2.0 fold amount in APA against essential hypertension and idiopathic hyperaldosteronism (IHA). However, its isolation and the structural analysis had not been executed until now.

Free Research Field

病態検査学