2015 Fiscal Year Final Research Report
Analysis of base excision repair in multiple myeloma
| Project/Area Number |
25460673
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory medicine
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
Murakami Hirokazu 群馬大学, 保健学研究科, 教授 (40166260)
|
|---|
| Research Collaborator |
Minato Yusuke
Kasamatsu Tetsuhiro
Gotoh Nanami
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 多発性骨髄腫 / 塩基除去修復遺伝子 / OGG1 / PARP-1 / 多型 |
|---|
| Outline of Final Research Achievements |
Polymorphism studies of base excision repair (BER) genes, including OGG1, XRCC1, APE1, MUTYH,and PARPI, showed that multiple myeloma （MM) patients with OGG1 Cys/Cys (low activity type) or PARP-1 non Val/Val (low activity type) were increased than health controls. Furthermore, mRNA expression of BER genes, incuding OGG1, APE1, and PARP-1 ,was increased in MM patiets. In additon, new generation PARP-1 inhibitor was effective in MM cell lines, suggesting inhibition of BER pathway may be a treatment opition in the future.
|
| Free Research Field |
血液検査学
|
