2016 Fiscal Year Final Research Report
Role of corticotropin-releasing factor receptor on gastric hyperalgesia associated with functional dyspepsia
| Project/Area Number |
25460718
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HORI Kiyomi 金沢大学, 医薬保健研究域医学系, 助教 (40595443)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 機能性胃腸症 / ストレス / 副腎皮質刺激ホルモン放出因子 / 肥満細胞 / 痛覚過敏 / 内臓痛 / CRF2 / urocortin |
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| Outline of Final Research Achievements |
Functional dyspepsia is defined as persistent or recurrent upper gastrointestinal tract symptoms such as pain without any obvious pathological changes. We examined the changes in pain sensation of the stomach after the stress in rat. In addition, involvements of corticotropin releasing factor (CRF), Type 2 CRF receptor (CRFR2) and CRF related peptides Urocortin (UCN) 1/2/3 in gastric hyperalgesia were investigated. Repeated WAS produced gastric hyperalgesia after the stress, with no obvious lesions in the gastric mucosa. Gastric hyperalgesia was inhibited by CRFR2 antagonists. CRF, CRFR2, and UCN1/2 positive cells existed in lamina propria. CRFR2 positive cells ware increased after WAS. Mast cells co-expressed CRFR2 or UCN2 in the lamina propria. WAS developed gastric hyperalgesia even in the absence of detectable gastric pathology, suggesting its suitability for a potential animal model of FD. CRFR2 play important roles in gastric hyperalgesia observed after the stress.
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| Free Research Field |
疼痛学
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