2015 Fiscal Year Final Research Report
Study of a role of ATP on a novel K+ channel in neuropathic pain.
| Project/Area Number |
25460731
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Hyogo University of Health Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Kohichi 兵庫医療大学, 薬学部, 助教 (30274848)
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| Co-Investigator(Renkei-kenkyūsha) |
DAI Tsuyoshi 兵庫医療大学, 薬学部, 教授 (20330441)
KOGURE Yoko 兵庫医療大学, 薬学部, 助教 (60548684)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 神経因性疼痛 / 脊髄後根神経節 / K+チャネル / 熱 / ATP / ATP受容体 |
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| Outline of Final Research Achievements |
To study the mechanism of generation of neuropathic pain, a role of adenosine-triphosphate (ATP) on a novel heat-activated K+ channel (Kheat) in dorsal root ganglion neurons of the rat was examined using a patch-clamp technique. Kheat was isolated by Ba2+ or tetraethylammonium. Under the isolation of Kheat, ATP did not affect to Kheat, as well as to TRPV1 receptors.
The reason of the less effect of ATP might be attribute to using normal rats but not neuropathic pain model rats in this study. To clear the problem, similar experiments will be continue in neuropathic pain model rats.
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| Free Research Field |
神経生理学
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