2015 Fiscal Year Final Research Report
A prospective study of Continuous Geriatric Assessments (GAs) in elderly advanced pancreatic cancer patients treated with gemcitabine-based chemotherapy
| Project/Area Number |
25460913
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 癌 / 医療・福祉 |
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| Outline of Final Research Achievements |
Background: We previously reported that the continuous geriatric assessments (GAs) were feasible in elderly pts with GI cancers. It is suggested that the changes in GAs might be useful. Methods: We conducted a prospective study in patients (pts) with pancreatic cancer. The primary end point was overall survival, and the secondary end points were progression free survival, toxicities, and quality of life. Eligible pts were aged 70 years or older; treating with GEM or GEM-nabPTX; and a Performance Status of 0-2. We performed the GAs before initial treatment and every two months after induction. The GAs were; Cancer-Specific Geriatric Assessment (CSGA), MMSE, Frontal Assessment Battery (FAB) and VES-13. Results: 52 pts were enrolled at Kyorin university hospital between July, 2013, and August, 2015. Conclusion: In elderly pts with pancreatic cancer, the continuous GAs were feasible. As this study is on-going, we will explore the relationship between the GAs and clinical outcomes.
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| Free Research Field |
老年腫瘍学
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