2015 Fiscal Year Final Research Report
Discovery and development of agents for chronic hepatitis C from marine natural products
| Project/Area Number |
25460985
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ENOMOTO Nobuyuki 山梨大学, 総合研究部, 教授 (20251530)
MORIISHI Koji 山梨大学, 総合研究部, 教授 (90260273)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | C型肝炎ウイルス / 治療薬 / 海洋生物 |
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| Outline of Final Research Achievements |
We focused on pharmacologically active component from marine organisms for the development of novel anti hepatitis C virus agent. Thus, we screened extracts of marine organisms by using HCV replicon system and showed that the extract from Amphimedon sp. inhibits HCV replication by suppressing viral helicase and protease activities. In this study, we attempted to purify and identify the active component of Amphimedon sp., but not purify and identify it. Additionally, we established a cell-based screening system in order to identify compounds inhibiting the HCV NS2/3 protease activity. We screened extracts of marine organisms by using this system, but not identify extracts of marine organisms inhibiting the HCV NS2/3 protease activity.
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| Free Research Field |
ウイルス学
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