2015 Fiscal Year Final Research Report
The role of impaired micro circulation or coagulopathy in chronic liver disease
| Project/Area Number |
25461016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUTSUI HIROKO 兵庫医科大学, 医学部, 教授 (40236914)
ENOMOTO HIRAYUKI 兵庫医科大学, 医学部, 准教授 (40449880)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 凝固亢進 / 肝障害 / 肝線維化 |
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| Outline of Final Research Achievements |
We examined the role of coagulopathy in chronic liver disease (CLD).Blood samples and liver tissues were taken from 15 chronic hepatitis (CH)-B, 27 CHC, 10 autoimmune hepatitis (AIH), and 8 non-alcoholic steatohepatitis (NASH).Von Willebrand factor (vWF) was high 8/15 in CHB, 14/27 in CHC, 6/8 in AIH, was low 4/8 in NASH. Thrombin and Antithrombin 3 complex (TAT) was high 3/15 in CHB, 4/27 in CHC, 3/11 in AIH, 2/8 in NASH. Protein C (PC) and S (PS) were low in 6/15 and 3/15 in CHB,10/27 and 9/27 in CHC, 2/10 and 1/10 in AIH,0/8 and 0/8 in NASH respectively. But these clotting factors rarely working simultaneously. Liver samples were analyzed by immunohistochemical staining. Both vWF-Ag and PAI-1 were stained uniformly in the liver tissue, especially around sinusoids.
Hypercoagulopathy (high vWF and low PC and PS) was found in CLD, lead to thrombin overproduction in some cases.
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| Free Research Field |
肝疾患
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