2015 Fiscal Year Final Research Report
Effect of inflammation of human cardiac adipose tissue on cardiomyocytes or on adipose-derived stem cells
| Project/Area Number |
25461067
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUSHITA Satoshi 順天堂大学, 医学部, 准教授 (20407315)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Taira 順天堂大学, 医学部, 准教授 (70301504)
INABA Hirotaka 順天堂大学, 医学部, 准教授 (10511454)
KUWAKI Kenji 順天堂大学, 医学部, 准教授 (90398313)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 臓器周囲脂肪 / 炎症 / アディポサイトカイン |
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| Outline of Final Research Achievements |
It has been proved that there is interaction between vessel and peripheral adipose tissue. In this study, we investigated the differences in quality of adipose tissue among subdermal (SD), around internal mammalian artery (IMA), and coronary artery (CA) in the patient with ischemic heart disease which is deeply associated with artery sclerotic disease. The adipose tissues were obtained during coronary artery grafting surgery. Expression of inflammation-related cytokines was the highest in CA, and the lowest in SD. Expression of angiogenesis-related cytokines was the highest in IMA. Expression of fibrosis-related cytokines was the highest in SD. These results indicated that adipose tissue may have different role depend on its location.
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| Free Research Field |
心臓血管外科
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