The great earthquake stress is associated to dysregulation of atherosclerosis-related genes in general population.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461138
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Iwate Medical University
• Principal Investigator: Satoh Mamoru 岩手医科大学, 医学部, 准教授 (90305996)
• Co-Investigator(Kenkyū-buntansha): ITOH Tomonori 岩手医科大学, 医学部, 教授 (30347851) ; MAESAWA Chihaya 岩手医科大学, 医学部, 教授 (10326647) ; ISHIKAWA Yuh 岩手医科大学, 医学部, 助教 (20583537) ; HACHIYA Tsuyoshi 岩手医科大学, いわて東北メディカル・メガバンク機構, 准教授 (20580088) ; SHIWA Yu 岩手医科大学, いわて東北メディカル・メガバンク機構, 講師 (00647753)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: DNAメチル化 / Small RNA / 動脈硬化性疾患 / 震災ストレス

Outline of Final Research Achievements

It has been already known that serial disasters, such as the great earthquake, is relate to an increased number of patients with coronary artery disease. Indeed, the number of patients with failing heart increased after the Great East Japan Earthquake (Nakamura et al. Am J Cardiol 2012). This study has investigated that the earthquake stress induces DNA methylation of atherosclerosis-related genes and abnormal profiling of small non-coding RNAs and then may be involve in the pathogenesis of atherosclerotic dieases.

Free Research Field

循環器内科