2015 Fiscal Year Final Research Report
Epigenetics of renin-angiotensin-aldosterone in salt-sensitive hypertension
| Project/Area Number |
25461244
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Research Collaborator |
TAKEDA Yoshimichi
WANG Fen
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | アンジオテンシノーゲン / エピゲノム / 高血圧 / 食塩感受性 / アルドステロン |
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| Outline of Final Research Achievements |
Salt-sensitive hypertension is the most popular disease in Japan. CYP11B2 gene expression was elevated and methylation ratio was decreased in human adrenal glomerulosa. High salt diet increased vascular CYP11B2 mRNA expression and angiotensinogen mRNA levels in the heart in salt-sensitive hypertensive rats. Hypomethylation status of angiotensinogen gene was seen in the heart. High salt diet may influence methylation status of genes of renin-angiotensin-aldosterone system and cause hypertension.
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| Free Research Field |
内分泌代謝
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