Biological characteristics of the novel erythropoietin designed to bind to Heparin-like Substances

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461410
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Niigata University
• Principal Investigator: MORIYAMA Masato 新潟大学, 医歯学系, 准教授 (30598131)
• Co-Investigator(Kenkyū-buntansha): OZAWA Takuya 新潟大学, 医歯学系, 助教 (70467075)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: エリスロポエチン / ヘパリン親和性 / サイトカイン / 造血活性 / 血管増殖阻害

Outline of Final Research Achievements

Erythropoietin (EPO) has been used as an erythropoietic stimulant, and it also shows tissue-protective effects. We synthesized a hybrid molecule of EPO;heparin-binding EPO (HEPO), and studied the characteristics of this novel EPO derivative. Human HEPO (rhHEPO) shows not only long-acting erythropoietic activity, but also antiangiogenic effect. This novel EPO derivative (HEPO) may have an advantage to inhibit tumor growth while preserving hematopoietic and tissue-protective effects.

Free Research Field

生物系 医師薬学 内科系臨床医学 血液内科学