2015 Fiscal Year Final Research Report
Elucidating common oncogenic pathway and generating anti-cancer agents
| Project/Area Number |
25461420
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kyoto University |
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Principal Investigator |
Kamikubo Yasuhiko 京都大学, 医学(系)研究科(研究院), 准教授 (60548527)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 白血病 / 低分子化合物 / 転写因子創薬 / 担癌マウスモデル / 肺癌 / 胃癌 |
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| Outline of Final Research Achievements |
I have elucidated that transcription factorA and its co-factorB are required for almost all leukemogenesis.It is quite important findings to isolate one of the best targets for leukemia therapy.I have generated novel anti-leukemia drugs D which extend the life spans of mice models such as PhALL(T315I)and MLL-AF4+FLT3-ITD dramatically, suggesting the transcription facorA is novel pro-oncogenic factor for leukemogenesis.On the other hand, Solid tumores such as EGFR Inhibitor resistant NSCLC, Her2 positive gastric cancer, neuroblastoma were also down-regulated by drug D in xeno-grafted mice models.We have already isolated several small molecules(HITS) through Super-computional simulation(MD)
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| Free Research Field |
血液・腫瘍学
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