• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2015 Fiscal Year Final Research Report

Where and how are mature platelets produced?

Research Project

  • PDF
Project/Area Number 25461458
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionIwate Medical University

Principal Investigator

Ishida Yoji  岩手医科大学, 医学部, 教授 (70151389)

Co-Investigator(Kenkyū-buntansha) KOWATA Syugo  岩手医科大学, 医学部内科学講座血液腫瘍内科分野, 教授 (30418884)
ITO Shigeki  岩手医科大学, 医学部腫瘍内科学科, 教授 (60316362)
Project Period (FY) 2013-04-01 – 2016-03-31
Keywordsmegakaryocyte / thrombocytopoiesis / proplatelet / thick protrusion / immature platelet
Outline of Final Research Achievements

How and where mature platelets are produced were investigated. Two evidences were obtained. The first, megakaryocytes in the bone marrow extended the proplatelets into the sinusoid and the proplatelet snapped, resulting in the immature platelets were released into the sinusoid in a steady state. The second, in the emergency state, in which a lot of platelets were demanded in thrombocytopenia, another immature platelets called "thick protrusion" were released into the sinusoid. These two types of immature platelets were converted into the mature platelets in the circulation.

Free Research Field

巨核球・血小板造血

URL: 

Published: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi