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2015 Fiscal Year Final Research Report

Human papillomavirus genotypes and HPV16 E6/E7 variants among patients with genital cancers in Asia

Research Project

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Project/Area Number 25461509
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Infectious disease medicine
Research InstitutionKanazawa University

Principal Investigator

ICHIMURA HIROSHI  金沢大学, 医学系, 教授 (10264756)

Co-Investigator(Kenkyū-buntansha) SASAGAWA Toshiyuki  金沢医科大学, 医学系, 教授 (30272975)
Co-Investigator(Renkei-kenkyūsha) ISHIZAKI Azumi  金沢大学, 医学系, 助教 (30456420)
BI Xiuqiong  金沢大学, 医学系, 助教 (50565413)
Project Period (FY) 2013-04-01 – 2016-03-31
Keywordsヒトパピローマウイルス / がん化 / HPV遺伝子型 / HPV E6・E7亜型 / ベトナム / 子宮頚癌 / 生殖器癌
Outline of Final Research Achievements

This study aimed to investigate human papilloma virus (HPV) genotype distribution and the HPV16 E6/E7 variations in Vietnamese patients with genital cancers, such as cervical, vulvar/vaginal, and penile cancers. The most prevalent HPV genotype in the women with normal cervical cytology (HPV52) was different from those in patients with genital cancers (HPV16/18). More than 85% of genital cancers could be prevented with the current vaccine targeting HPV 16/18 in Vietnam. HPV16 E6/E7 European Asian lineage may be less oncogenic. The G to A and C to T mutations at specific nucleotide positions of HPV16 E6/E7 genes may be involved in the development of cancers.

Free Research Field

ウイルス学、感染症制御学、国際保健学

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Published: 2017-05-10  

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