2015 Fiscal Year Final Research Report
Analysis of vaccine-mediated immune induction in Mucopolysaccharidosis-specific iPS cells
| Project/Area Number |
25461558
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Osaka City University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | ワクチン / 自然免疫 / 小児 / 感染症 / 単球 / サイトカイン |
|---|
| Outline of Final Research Achievements |
When Toll-like receptor (TLR)-mediated innate immune response was compared between Mucopolysaccharidosis (MPS)-specific cells and control iPS cells, zymosan or MALP2-mediated cytokine levels were significantly lower in MPS-specific iPS cells-derived dendritic cells compared to control iPS cells-derived dendritic cells. Then, when TLR-mediated innate immune response was compared between healthy neonates and healthy adults, immaturity of TLR-mediated immune response was disclosed to depend on cell types and TLR types in neonates, however zymosan provided comparable immune response between neonates and adults. Therefore, vaccine using zymosan as an adjuvant may play a key role in vaccine development for MPS children.
|
| Free Research Field |
粘膜免疫学
|
