Re-evaluation of clinical effectiveness of four neuraminidase inhibitors against influenza viruses using molecular biology and epidemiological studies

2016 Fiscal Year Final Research Report

• Project/Area Number: 25461577
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Hokkaido University
• Principal Investigator: Ishiguro Nobuhisa 北海道大学, 大学病院, 准教授 (40168216)
• Co-Investigator(Renkei-kenkyūsha): SAKODA YOSHIHIRO 北海道大学, 獣医学研究院, 教授 (40333637)
• Research Collaborator: KAIHO MIKI 北海道大学, 医学研究科, 技術補助員
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: インフルエンザ / ノイラミニダーゼ阻害薬

Outline of Final Research Achievements

Four anti-neuraminidase inhibitors (laninamivir, oseltamivir, peramivir and zanamivir) are now available for treatment of influenza virus infection. The purpose of this study was clinical evaluations of four anti-neuraminidase inhibitors for treatment of influenza virus infection. We reached the following conclusion; (1) oseltamivir and peramivir had advantages over laninamivir and zanamivir in treating patients (0 to 18 years old) infected with influenza A viruses, (2) laninamivir and zanamivir had advantages over oseltamivir and peramivir in treating patients (0 to 18 years old) infected with influenza B viruses.

Free Research Field

感染症