2016 Fiscal Year Final Research Report
Elucidation of the pathophysiology of Langerhans cell histiocytosis by chemokine analysis
| Project/Area Number |
25461606
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | ランゲルハンス細胞組織球症 / ケモカイン / osteopontin / 破骨細胞様巨細胞 / 遺伝子多型 |
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| Outline of Final Research Achievements |
The serum levels of IL-9, IL-10, IL-15 and MIF in patients with Langerhans cell histiocytosis (LCH) were significantly high compared to those in Control. The serum levels of M-CSF and CCL 2 in patients with multisystem (MS) type LCH were significantly high compared to those in patients with single-system (SS) type LCH, while the serum levels of IL-18 and osteopontin (OPN) in patients with risk organ involvement (RO) positive MS type LCH were significantly high compared to those in patients with RO negative MS type LCH.
OPN was revealed to be essential for differentiation from immature dendritic cells to osteoclast-like giant cells.
In 48 LCH patients, OPN gene polymorphisms (rs9138, rs4754, rs11730582, rs1126772, rs1126616) were analyzed. No significant difference was identified in allele frequencies of these sites between LCH patients and controls, patients diagnosed under 2-years-old and over 2-years-old, patients with MS type and SS type, patients with MS-RO (+)and MS-RO (-).
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| Free Research Field |
小児血液学
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