2016 Fiscal Year Final Research Report
The effects of hydrogen gas inhalation for hypoxic-ischemic encephalopathy in piglets.
| Project/Area Number |
25461647
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 新生児低酸素性虚血性脳症 / 水素ガス / 低体温療法 / 近赤外線分光法 / 脳血液量 / 脳内Hb酸素飽和度 / 新生仔豚 / 新生児仮死 |
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| Outline of Final Research Achievements |
The aim of this study is to evaluate the effectiveness of free radical scavenger (edaravone, EV) combined with hypothermia (HT) for hypoxic-ischemic (HI) brain injury, and the safety of hydrogen gas inhalation in neonatal piglets. The following results had been reported. At first, there was a positive linear correlation between changes in cerebral blood volume and low-amplitude aEEG duration during 12 h after the insult in the no-therapy group, but a negative linear correlation between these two parameters in the HT group. Secondly, both HT and HT+EV groups showed lower histopathological cerebral damages compared to that of no-therapy, especially in gray and white matter. However, HT+EV did not show lower damages compared to HT. Lastly, hydrogen gas inhalation had no effects on circulatory and metabolic activities, especially cerebral hemodynamics and oxygen metabolism, and cortical electrical activity. Therefore, hydrogen gas is likely to be used safely in neonatal medicine.
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| Free Research Field |
新生児学
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