Comparison between psychophysiological insomnia and residual insomnia of the depression using the brain imaging analysis

2016 Fiscal Year Final Research Report

• Project/Area Number: 25461795
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Neuropsychiatric Research Institute
• Principal Investigator: Nakamura Masaki 公益財団法人神経研究所, 研究部(代々木), 研究員 (70375054)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: MRS / 不眠 / 脳画像 / 海馬 / 前帯状回 / グルタミン酸

Outline of Final Research Achievements

The participants were six healthy control subjects and 6 patients with chronic insomnia. We examined the MRS Signals of the anterior cingulate gyrus, ventrolateral preoptic area (VLPO), brainstem reticular formation, and hippocampi to estimate the relative concentrations of NAA, lactate, choline, mI, lipids, and glutamine and glutamate complex (Glx). Sleep state, level of predisposition to insomnia, dysfunctional beliefs about insomnia, as well as depressive symptoms, were each assessed by ISI-J, FIRST, DBAS, and BDI-II. In both groups, the ISI and BDI scores were positively correlated with the levels of Glx in the right hippocampus, and the FIRST scores were positively correlated with the levels of lipids in the anterior cingulate gyrus. In the insomnia group, the total DBAS score and the “sleep expectations” in a subcategory were observed to be positively correlated with the lipid levels in the right hippocampus and the levels of Glx in the anterior cingulate gyrus, respectively.

Free Research Field

医歯薬学・精神神経科学