Clinical efficacy of PET/CT using 68Ga-labeled octreotide

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461816
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: NAKAMOTO Yuji 京都大学, 医学(系)研究科(研究院), 准教授 (20360844)
• Co-Investigator(Kenkyū-buntansha): TEMMA Takashi 京都大学, 大学院薬学研究科, 助教 (90378787)
• Co-Investigator(Renkei-kenkyūsha): SANO Kohei 京都大学, 大学院医学研究科, 助教 (00546476) ; MASUI Toshihiko 京都大学, 大学院医学研究科, 講師 (20452352) ; YASODA Akihiro 京都大学, 大学院医学研究科, 講師 (50378642)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: がん / 画像診断 / ポジトロン断層撮像法 / 神経内分泌腫瘍 / オクトレオタイド

Outline of Final Research Achievements

Clinical efficacy of positron emission tomography using 68Ga-labeled octreotide has not been investigated in Japan so far. We applied DOTATOC-PET/CT in patients with neuroendocrine tumors. It provided useful information for making therapeutic strategies especially when recurrence had been suspected due to their higher hormone levels after resection of histologically-proven neuroendocrine tumors. On the other hand, it was indicated that information obtained by DOTATOC-PET/CT should be minimum simply when hormone levels were high without history of neuroendocrine tumors. In PET with fluorodeoxyglucose, dual-phase scanning sometimes yields significant information in clinical, but it was not helpful in DOTATOC-PET/CT because a sufficient tumor-to-background ratio can be obtained at 1-hr post-injection. As for the physiological uptake, pancreatic uncus was considered to be a pitfall in evaluating DOTATOC-PET images.

Free Research Field

画像診断学