DNA damage induced by radiation exposure at CT

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461825
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hiroshima University
• Principal Investigator: AWAI Kazuo 広島大学, 医歯薬保健学研究院(医), 教授 (30294573)
• Co-Investigator(Kenkyū-buntansha): NAKANO Yukiko 広島大学, 病院(医), 講師 (10397911) ; Ishida Mari 広島大学, 医歯薬保健学研究院, 講師 (30359898)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: CT / DNA / X線被曝 / gamma-H2Ax

Outline of Final Research Achievements

We investigated whether physical exposure parameters such as CTDI, DLP, and SSDE are predictive of the level of radiation-induced DNA damage.　In our in vitro study we scanned a phantom containing blood samples from 5 healthy　volunteers at CTDI 0-, 50-, 100-, and 150 mGy. In the in vivo study we enrolled 45 patients who underwent cardiac CT before ablation therapy. We obtained their blood samples before- and 15 minutes after CT and before ablation therapy. The number of γ-H2AX foci in lymphocytes was measured both studies. DNA damage was induced by radiation exposure from cardiac CT. There was a significant correlation between the physical exposure parameters and the induction of γ-H2AX. Our data suggest that the actual effect of CT radiation on the human body can be estimated by using physical exposure parameters.

Free Research Field

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