Experimental study on control of the drug distribution in transarterial infusion

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461872
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: Koda Wataru 金沢大学, 医学系, 准教授 (30401920)
• Co-Investigator(Kenkyū-buntansha): MATSUI Osamu 金沢大学, 医薬保健学総合研究科, 特任教授 (10019961) ; MINAMI Tetsuya 金沢大学, 附属病院, 准教授 (60436813) ; YOSHIDA Kotaro 金沢大学, 医学系, 助教 (30645130)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: インターベンショナルラジオロジー（IVR） / 癌 / 血管透過性

Outline of Final Research Achievements

To develop specific, effective and non-invasive delivery system using IVR technology, we investigated the relationship of vasoactive substances to vascular permeability. By photoacoustic imaging, it was possible to confirm the kinetics of indocyanine green (ICG) and ICG uptake into the cells. In addition, the tissue accumulation of Evans blue was enhanced in the state of increased vascular permeability, and the signal of a photoacoustic imaging by ICG was reduced in the state of decreased vascular permeability.

Free Research Field

放射線科学