2015 Fiscal Year Final Research Report
High precision radiation therapy based on intra-tumoral hypoxic imaging
| Project/Area Number |
25461932
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TACHIBANA Izumi 近畿大学, 医学部, 講師 (00510984)
ISHIKAWA Kazuki 近畿大学, 医学部, 助教 (10511016)
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| Co-Investigator(Renkei-kenkyūsha) |
HOSONO Makoto 近畿大学, 医学部附属病院, 教授 (00281303)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 放射線療法 / 低酸素領域 / ミソニダゾール / 再酸素化 / 効果予測 / PET/CT |
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| Outline of Final Research Achievements |
18F-fluoromisonizazole (F-MISO) PET/CT is a non-invasive method of depicting tumor hypoxia. A prospective clinical trial of F-MISO PET/CT for patients scheduled for radiotherapy (RT) was conducted. F-MISO above a value of 1.60 SUV was regarded as indicating a hypoxic area based on our previous study. Of the 22 tumors examinied, 18 tumors had hypoxic area before RT. For 17 patients, F-MISO PET/CT was performed twice before and during fractionated RT. Except for one nasopharyngeal cancer, 16 of the 17 tumors showed a decrease in hypoxic indicators, indicating reoxygenation. Local control rate of patients with SUVmax <2.0 was significantly better than that of patients with SUVmax =>2.0 (p=0.03). Also, overall survival rate of patients with SUVmax <2.0 was significantly better than that of patients with SUVmax =>2.0 (p=0.004). In conclusion, most human tumors contain hypoxic areas before treatment. F-MISO SUVmax =>2.0 before treatment may predict poor prognosis by RT.
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| Free Research Field |
放射線腫瘍学
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