2015 Fiscal Year Final Research Report
Development of new chemotherapeutic agents using monoterpenes
| Project/Area Number |
25462069
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Yokohama City University (2015)
University of Tsukuba (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 大腸癌 / モノテルペン / 化学療法 |
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| Outline of Final Research Achievements |
Monoterpenes are derived from natural plants and some of them have anti-tumor activity. We evaluated three kinds of monoterpenes, 1,8-cineole, terpinen 4-ol, and linalool, induced apoptosis in human colon cancer cell line HCT116 and RKO. In xenotransplanted SCID mice, these monoterpenes significantly inhibited tumor progression compared to control. Based on these studies, monoterpenes iwould be an effective strategy to treat unresectable colorectal cancer tumor especially 1,8-cineole, terpinen 4-ol, and linalool.
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| Free Research Field |
消化器外科学
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