Development of prognostic prediction system based on novel pathological prognostic indicators and Nomogram in colorectal cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 25462075
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: National Defense Medical College
• Principal Investigator: Ueno Hideki 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 外科学, 教授 (90597535)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 大腸癌 / 予後 / Nomogram / 簇出 / 低分化胞巣 / 線維性癌間質 / 非連続性癌進展 / 神経浸潤

Outline of Final Research Achievements

The purpose of this study was to develop a novel prognostic prediction system in colorectal cancer (CRC) through identifying new pathological prognostic factors. We identified 5 new pathological factors with original assessment criteria, which had prognostic power superior to other conventional factors. In a multicenter database of CRC patients, we developed a prognostic prediction model (Nomogram) with favorable prognostic prediction power. It is determined that our results will be validated in a domestic multicenter clinical study and are now being fully utilized to develop study design of another clinical trial. Furthermore, a series of our results have been paid attention from the West and it has been determined to launch an international study for new pathological factors involving 8 countries. We believe our study products are expected to further contribute to the establishment of personalized CRC treatment through such domestic and international initiatives.

Free Research Field

大腸癌