Development of selective cerebral perfusion to prevent brain injury in children with congenital cardiac diseases and its application for adult patients

2016 Fiscal Year Final Research Report

• Project/Area Number: 25462139
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Nagoya City University
• Principal Investigator: MISHIMA Akira 名古屋市立大学, 大学院医学研究科, 教授 (00254277)
• Research Collaborator: ISHIDA Akimasa 名古屋市立大学, 大学院医学研究科, 助教 (20632607)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 選択的脳灌流 / 脳虚血モデル / 肺高血圧 / 低酸素血症 / 若齢ラット

Outline of Final Research Achievements

In cardiac surgery of children with anomaly of the aortic arch, brain blood is supplied by a particular method, called selective cerebral perfusion under using cardiopulmonary bypass. We devised a simple selective cerebral perfusion model on rats. To develop an adequate procedure for children with cyanosis, we conducted experiment on selective cerebral perfusion in juvenile rats bred under hypoxic environment. Neural damage of brain was investigated with a special microscopic examination that detected early neural injury. Brain damage caused by the selective cerebral perfusion was more serious in juvenile rats bred under hypoxic environment than in normal rats. So, we should be careful about the selective cerebral perfusion of children with cyanosis.

Free Research Field

心臓血管外科学