2016 Fiscal Year Final Research Report
Molecular mechanism for enhanced constriction of coronary artery bypass graft in patients with diabetes mellitus
| Project/Area Number |
25462154
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Kyushu University of Health and Welfare |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 冠動脈バイパス手術 / 糖尿病 / 伏在静脈 / 内胸動脈 / スパズム / セロトニン / アンジオテンシンⅡ |
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| Outline of Final Research Achievements |
Bypass grafts harvested from Diabetes mellitus (DM) patients tend to spasm after implantation into coronary circulation. Our mine findings are that ①angiotensin II (Angll)- and 5-HT-induced constrictions of human endothelium-denuded saphenous vein (SV) and internal thoracic artery (ITA) were significantly greater in the DM group than in the non-DM group. ②The protein level of the Angll and 5-HT2A receptors in the membrane fraction of ITA smooth muscle cells were significantly increased in the DM group compared with the non-DM group. ③However, only Angll receptor, but not 5-HT2A receptor, in the membrane fraction of human SV smooth muscle cells was significantly increased in the DM group. Our findings suggest that the molecular mechanisms for 5-HT-induced hyper reactivity in an arterial graft are different from those in a venous graft.
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| Free Research Field |
薬理学
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