2015 Fiscal Year Final Research Report
Imaging of malignant brain tumor after treatment with VEGF inhibitor
| Project/Area Number |
25462262
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Kurisu Kaoru 広島大学, 医歯薬保健学研究院, 教授 (70201473)
Sugiyama Kazuhiko 広島大学, 病院, 教授 (30243554)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | glioblastoma / malignant lymphoma / DWI / 1HMRS / VEGF / cavernous angioma / cranial irradiation |
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| Outline of Final Research Achievements |
We investigated the risk factors for brain apoplexy after VEGF treatment. Our study indicated that hemorrhagic apoplexy developed within 3 months、while thromboembolic apoplexy develop 6 months after VEGF treatment, and related to risk factor of brain infarction including hypertension. Our study revealed that the relationship between tumor location and the lesion of DWI high intensity was important for differentiation between true- and pseudo-response after bevacizumab treatment. Large lipid peaks on 1H-MRS images of tumors without central necrosis were characteristic of malignant lymphomas. Conversely, small or absent lipid peaks in intraaxial tumors without central necrosis were strongly suggestive of glioma. Patients who underwent radiation therapy with primitive neuroectodermal tumors or pineoblastoma developed Zabramski type 1 and 2 CVA significantly earlier than did medulloblastoma patients.
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| Free Research Field |
Neurosurgery
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