2016 Fiscal Year Final Research Report
The study to construct a new thrapy for malignant glioma stem cell using a cell penetrating peptide
| Project/Area Number |
25462273
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
Nakamura Hideo 熊本大学, 医学部附属病院, 講師 (30359963)
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| Co-Investigator(Renkei-kenkyūsha) |
TOMIZAWA Kazuhito 熊本大学, 生命科学研究部, 教授 (40274287)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | Glioma Stem cell / penetrating peptuide / autophagy / micelle |
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| Outline of Final Research Achievements |
Glioblastoma is resistant to chemotherapy and radiation therapy. Therefore, to overcome this resistancy, we planned the experiment using cell-penetrating peptide. This peptide were wrapped by a Micelle to be delivered the tumor cells in vivo. Glioma Stem Cell (GSC) were established from surgical samples and as soon as possible they were injected to nude mice. Autophagy was observed by several experiments using this cell-penetrating peptide. We need more animal experiments to testify these phenomenon.
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| Free Research Field |
Brain tumor biology
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