2017 Fiscal Year Final Research Report
Applicaition of radiosensitizing effect of 5-aminolevulinic acid for malignant glioma therapy
| Project/Area Number |
25462282
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
|
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2018-03-31
|
| Keywords | 5－アミノレブリン酸 / グリオーマ / 放射線治療 / ミトコンドリア / 活性酸素種 |
|---|
| Outline of Final Research Achievements |
We assessed mechanism of radiosensitizing effect of 5-aminolevulinic acid (ALA) in glioma cells focusing on the delayed production of reactive oxygen species (ROS) after ionizing irradiation and mitochondria. 5-ALA induces enhancement of delayed ROS production and host antitumor response in glioma.
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| Free Research Field |
脳腫瘍学
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