Effects of internal fixation for metastatic bone tumor.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462350
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Osaka City University
• Principal Investigator: Terai Hidetomi 大阪市立大学, 大学院医学研究科, 准教授 (20382046)
• Co-Investigator(Kenkyū-buntansha): DOUZONO Shou 大阪市立大学, 大学院医学研究科, 登録医 (10618945) ; TOYODA Hiromitsu 大阪市立大学, 大学院医学研究科, 講師 (50514238) ; NAKAMURA Hiroaki 大阪市立大学, 大学院医学研究科, 教授 (60227931)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 骨転移 / 内固定 / 生命予後 / 骨破壊 / VX-2 / 転移性骨腫瘍 / 悪性腫瘍 / 癌

Outline of Final Research Achievements

Treatment of bone metastasis is a big issue in the aged society because people with tumor increase as aging. We succesfully developed the metastatic bone model of rabbit using VX-2 carcinoma cells implanted into their tibiae. Furthermore, we have proved that prophylactic internal fixation of metastatic bone prevented bone distruction and improve the survival rate of metastatic rabbit. Further study is required to clarfy its mechanism.

Free Research Field

整形外科学