Abnormal fetal heart rate pattern and fetomaternal hemorrhage

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462546
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Hokkaido University
• Principal Investigator: Minakami Hisanori 北海道大学, 医学(系)研究科(研究院), 特任教授 (40102256)
• Co-Investigator(Kenkyū-buntansha): Morikawa Mamoru 北海道大学, 大学院医学研究科, 講師 (00374380) ; Yamada Takahiro 北海道大学, 大学院医学研究科, 特任講師 (20419948)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: αフェトプロティン / fetomaternal hemorrhage / 前置胎盤 / 常位胎盤早期剥離 / 妊娠高血圧腎症

Outline of Final Research Achievements

Women with preeclampsia, placenta previa (PP), placental abruption (PA), and placental mesenchymal dysplasia (PMD) were suggested to have placental permeability dysfunction. This study aimed to determine whether occult fetomaternal hemorrhage (FMH) is common in women with such complications. 41 antenatal and 39 postnatal blood samples were obtained from 46 women consisting of 11 with placental permeability dysfunction (5, 3, 2, and 1 with preeclampsia, PP, PA, and PMD, respectively) and 35 controls without such complications. FMH was identified in five women, including one each with preeclampsia, PA, PP, PMD, and nocomplications. Thus, the prevalence rate of FMH was significantly higher in women with complications than in controls (36% [4/11] vs. 2.9% [1/35]). The risk of fetal RBC trafficking into the maternal circulation may be increased in women complicated with preeclampsia, PA, PP, and PMD.

Free Research Field

周産期医学