2015 Fiscal Year Final Research Report
Chromatin remodeling and reprogramming with oocyte specific linker histone,
| Project/Area Number |
25462580
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University (2015)
St. Marianna University School of Medicine (2013) |
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Principal Investigator |
Tanaka Mamoru 慶應義塾大学, 医学部, 教授 (20207145)
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| Co-Investigator(Kenkyū-buntansha) |
河村 和弘 聖マリアンナ医科大学, 医学部, 准教授 (10344756)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | リンカーヒストン / 卵子 |
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| Outline of Final Research Achievements |
Oocyte-specific linker histone H1foo is expressed in oocyte and early stage embryos. H1foo is essential for in vitro meiotic maturation of oocyte. The greater mobility of H1foo, compared with H1, may contribute to this rapid replacement and the instability of chromatin structure. These findings suggest that the rapid replacement of H1 with H1foo may play an important role in nuclear remodeling.
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| Free Research Field |
産婦人科
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