Effect of menthol on patients with olfactory disorder due to chronic rhinosinusitis.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462671
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Hyogo Medical University
• Principal Investigator: Tsuzuki Kenzo 兵庫医科大学, 医学部, 准教授 (50441308)
• Co-Investigator(Renkei-kenkyūsha): KATSURA Hirokazu 兵庫医科大学, 医学部, 講師 (90533761)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 慢性副鼻腔炎 / 好酸球性副鼻腔炎 / 嗅覚障害 / メントール / 膝神経節

Outline of Final Research Achievements

We studied about patients with chronic rhinosinusitis (CRS) in the pre-, intra-, and postoperative stages for endoscopic sinus surgery (ESS). Olfaction were investigated using a test for research including menthol as smells item, T&T recognition threshold test, and intravenous olfaction test. We proposed a novel scoring for operating findings during ESS according to mucosal condition and sinus contents. We, further, reported a novel scoring for postoperative endoscopic endonasal findings (E score), and evaluated its variability and usefulness. We reported that olfactory disorder and E scores in patients with eosinophilic CRS (ECRS) were significantly worse than those in patients with non-ECRS. We found that decreased expression levels of transient receptor potential vanilloid 1 (TRPV1) and transient receptor potential melastatin 8 (TRPM8) in uninjured neurons in ipsilateral rat geniculate ganglion (GG) after chorda tympani nerve injury.

Free Research Field

耳鼻咽喉科