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2015 Fiscal Year Final Research Report

Diabetic retinopathy treatment targeting PPAR gamma

Research Project

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Project/Area Number 25462717
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionThe University of Tokushima

Principal Investigator

MITAMURA Yoshinori  徳島大学, 大学院医歯薬学研究部, 教授 (30287536)

Co-Investigator(Kenkyū-buntansha) HOTTA Fumika  徳島大学, 病院, 医員 (80645838)
EGAWA Mariko  徳島大学, 大学院医歯薬学研究部, 講師 (70507657)
MINO Akiko  徳島大学, 病院, 助教 (50531836)
Co-Investigator(Renkei-kenkyūsha) HARADA Takayuki  公益財団法人東京都医学総合研究所, 視覚病態プロジェクト, 副参事研究員 (90345306)
Project Period (FY) 2013-04-01 – 2016-03-31
Keywords外科 / 細胞・組織 / 生体分子 / 糖尿病 / 臨床
Outline of Final Research Achievements

Peroxisome proliferator-activated receptor gamma (PPARγ) was detected in the exosome fraction of the culture media of human umbilical vein endothelial cells, indicating that PPARγ, a nuclear protein, can be released into the extracellular fluid. PPARγ mRNA expression levels in membrane samples, and the PPARγprotein concentrations in aqueous humor and vitreous fluid samples were significantly higher in patients with proliferative diabetic retinopathy (PDR) than control patients. We observed a significant positive correlation between the PPARγlevels and vascular endothelial growth factor levels or clinical stage of retinopathy in the aqueous humor and vitreous fluid of PDR patients. Taken together, PPARγ may be a therapeutic target for diabetic retinopathy.

Free Research Field

医歯薬学

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Published: 2017-05-10  

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