Exploratory research about intraocular inflammation refractory marker using newly developed carbohydrate structural analysis; Glycoblottoing

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462745
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Hokkaido University
• Principal Investigator: NAMBA KENICHI 北海道大学, 大学病院, 講師 (70333599)
• Co-Investigator(Kenkyū-buntansha): KITAICHI NOBUYOSHI 北海道医療大学, 個体差医療科学センター, 教授 (40431366) ; NISHIMURA SHINICHIRO 北海道大学, 先端科学研究科(研究院), 教授 (00183898) ; AMANO MAHO 北海道大学, 先端生命科学研究科(研究院), 特任助教 (80365808)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 網膜ぶどう膜炎 / ベーチェット病 / 糖鎖解析 / 炎症増悪マーカー

Outline of Final Research Achievements

In this study we examined about the specific carbohydrate chains associated with refractory intraocular inflammations. Glycoblottoing which was newly developed carbohydrate structural analysis was performed with the serum of 2 groups; 1) Behcet’s disease patients who were refractory to infliximab treatment and were positive of anti-infliximab antibody. 2) Behcet’s disease patients who were well controlled with infliximab treatment. Four carbohydrate chains; m/z1680, m/z2337, m/z2379, m/z3195 were detected with significant difference between 2 groups, and all of them were increased in refractory patients.

Free Research Field

ぶどう膜炎